For Mac OS X users: cisortho cannot be run by clicking the icon (I would have liked to implement this feature, but could not...) To run cisortho (or cis) follow these steps: 1. open a terminal. 2. at the prompt, type: cd where is the directory (e.g. /Users/joe/) where you downloaded cisortho and cis. 3. type: ls -la cisortho you will see something like: -rwxr-xr-x 1 joe joe 2643236 Jan 16 15:57 cisortho 4. if the file is not 'executable', i.e. does not have 'x' in the permissions string, type: chmod 755 cisortho 5. launch by typing: ./cisortho At this point, you should see the CisOrtho welcome message, which will guide you further.