Brugia malayi is a gonochoristic (male-female) filarial parasite, of medical interest because it infects mosquito vectors (Aedes,Anopheles, and Culex) and humans, and is phylogenetically representative of other infectious nematodes. Infection of humans by B. malayi causes filariasis.
It has the following Web resources:
An article describing its genomic sequence.
A Wolbachia strain TRS at EnsEMBL Genomes for information on the Wolbachia endosymbiont.
A review of nematode phylogeny from WormBook.
Information on B. malayi from the Blaxter laboratory.
Information on filariasis from the CDC.
In silico predictions of possible drug targets in B. malayi.
Genomic data from the nematode sequencing project at the Washington University Genome Sequencing Center.
The Filiarisis Research Reagent Center providing strains and reagents.
NOTE: WormBase is a scientific database for experimental work on C. elegans and other laboratory nematodes: it is not a resource for medical information, it is not run or staffed by clinicians, and it should not be used as a source of advice on parasitic nematode infections. If you need such advice, please contact a qualified physician, preferably one trained in parasitic diseases.
Sex Determination: gonochoristic
Haploid No. chromosomes: 5 (4 autosomes, XY)
March 2016
WormBase released an assembly improved by adding PacBio and Optical Map information. Identifiers were preserved as far as possible and the respective history for merges/splits shown.
April 2013
WormBase released a new assembly and gene set in coordination with the Brugia malayi community. The new assembly is based on next-gen sequencing and provided by the University of Pittsburgh. Genes were predicted by a combination of RNASeq and various gene prediction programs. In addition on 20% of the predicted genes manual curation was performed (with priority on genes of community interest).
The data is available on 3rd party sites like INSDC and UniProt.
December 2010
WormBase shows a merged gene set.
The Transcripts with ids like Bm1_57650A are from the original TIGR data, and the ones with ids like BMAL5.1 are from Erich Schwartz's Augustus prediction set.
We merged overlapping transcripts on the same strand into genes, and removed isoforms, that are substrings of another one (based on 100% DNA and exon boundary identity, and no internal stops in the larger isoform).