Predicted to enable histone methyltransferase activity and metal ion binding activity. Involved in determination of adult lifespan. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 23; esophagus squamous cell carcinoma; and prostate cancer. Is an ortholog of human SETD5 (SET domain containing 5).
Enriched in neurons based on RNA-seq studies. Is affected by several genes including adr-1; tdp-1; and set-9 based on RNA-seq studies. Is affected by methylmercury hydroxide based on RNA-seq studies.
Enables histone H3K9 methyltransferase activity. Predicted to be involved in chromatin remodeling and methylation. Predicted to be located in nucleus. Expressed in several structures, including germ cell; hypodermis; intestine; muscle cell; and somatic cell.