gene: glr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic density membrane. Expressed in DVA; M1 neuron; linker cell; nerve ring; and neurons. Human ortholog(s) of this gene implicated in intellectual disability (multiple) and schizophrenia. Is an ortholog of several human genes including GRIA1 (glutamate ionotropic receptor AMPA type subunit 1); GRIA2 (glutamate ionotropic receptor AMPA type subunit 2); and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3).