gene: egl-38 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including developmental process involved in reproduction; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of chromatin. Expressed in body wall musculature; egg-laying apparatus; head neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital nongoitrous hypothyroidism 2; focal segmental glomerulosclerosis 7; and renal Wilms' tumor. Is an ortholog of human PAX2 (paired box 2); PAX5 (paired box 5); and PAX8 (paired box 8).