gene: egrh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of oocyte maturation and negative regulation of ovulation. Located in nucleus and perinuclear region of cytoplasm. Expressed in body wall musculature; hermaphrodite somatic gonadal cell; nervous system; pharynx; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); lung disease (multiple); and neuropathy (multiple). Is an ortholog of human EGR1 (early growth response 1) and EGR3 (early growth response 3).
sequence feature: WBsf718777
Caenorhabditis elegans This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=C27C12.2. Surounding gene organisation=tandem
sequence feature: WBsf718776
Caenorhabditis elegans This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=C27C12.2. Surounding gene organisation=tandem