gene: unc-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including endocytosis; necroptotic process; and protein localization to postsynaptic membrane. Located in clathrin-coated pit and presynaptic membrane. Expressed in several structures, including epithelial cell; excretory gland cell; pharyngeal gland cell; rectal gland cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and acute myeloid leukemia. Is an ortholog of human PICALM (phosphatidylinositol binding clathrin assembly protein) and SNAP91 (synaptosome associated protein 91).