gene: sphk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable D-erythro-sphingosine kinase activity and acetyltransferase activity. Involved in mitochondrial unfolded protein response; positive regulation of acetylcholine secretion, neurotransmission; and regulation of locomotion. Located in several cellular components, including mitochondrion; neuronal cell body; and presynaptic periactive zone. Expressed in several structures, including body wall musculature; excretory canal; intestine; linker cell; and neurons. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human SPHK1 (sphingosine kinase 1) and SPHK2 (sphingosine kinase 2).
sequence feature: WBsf717740
Caenorhabditis elegans This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=C34C6.5. Surounding gene organisation=tandem