gene: hcf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and regulation of DNA-templated transcription. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Located in nucleus. Part of transcription regulator complex. Expressed widely. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Is an ortholog of human HCFC1 (host cell factor C1) and HCFC2 (host cell factor C2).