gene: vhl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in response to hypoxia. Part of Cul2-RING ubiquitin ligase complex. Expressed in several structures, including ADFL and ADFR. Used to study clear cell renal cell carcinoma and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial erythrocytosis 2; and von Hippel-Lindau disease. Is an ortholog of human VHL (von Hippel-Lindau tumor suppressor).