gene: clr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of fibroblast growth factor receptor signaling pathway; netrin-activated signaling pathway; and positive regulation of synapse assembly. Located in plasma membrane and postsynapse. Expressed in several structures, including AVA; body wall musculature; muscle cell; preanal ganglion; and somatic gonad. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; multiple sclerosis; and severe combined immunodeficiency. Is an ortholog of human PTPRC (protein tyrosine phosphatase receptor type C); PTPRG (protein tyrosine phosphatase receptor type G); and PTPRZ1 (protein tyrosine phosphatase receptor type Z1).