gene: ufd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in ER-associated misfolded protein catabolic process; embryo development; and positive regulation of protein localization to nucleus. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Used to study velocardiofacial syndrome. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Is an ortholog of human UFD1 (ubiquitin recognition factor in ER associated degradation 1).