gene: isp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c; positive regulation of nematode larval development; and regulation of macromolecule metabolic process. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex III. Expressed in head and tail. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Is an ortholog of human UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) and UQCRFS1P1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 pseudogene 1).