Enriched in head mesodermal cell; neurons; pharynx; retrovesicular ganglion; and ventral nerve cord based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
sir-2.1;
sek-1; and
pgl-1 based on microarray and RNA-seq studies. Is affected by seven chemicals including stavudine; allantoin; and metformin based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Human MAPK8IP1 enables MAP-kinase scaffold activity and kinesin binding activity. Is predicted to encode a protein with the following domains: PH-like domain superfamily; Phosphotyrosine interaction domain (PTB/PID); SH3-like domain superfamily; SH3 domain; PTB/PI domain; and Variant SH3 domain. Is an ortholog of human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1).