Enriched in several structures, including Z1.p; body wall muscle cell; germ line; germline precursor cell; and male distal tip cell based on tiling array; RNA-seq; and microarray studies. Is affected by several genes including
skn-1;
daf-12; and
hsf-1 based on tiling array; RNA-seq; and microarray studies. Is affected by thirteen chemicals including aldicarb; rotenone; and D-glucose based on microarray and RNA-seq studies. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Sponastrime type. Human TONSL enables histone binding activity and histone reader activity. Is predicted to encode a protein with the following domains: Ankyrin repeats (3 copies); Ankyrin repeat; Ankyrin repeats (many copies); Leucine-rich repeat domain superfamily; Ankyrin repeat-containing domain superfamily; Tetratricopeptide-like helical domain superfamily; Putative ankyrin repeat domain-containing protein 31; and Phosphorylation site. Is an ortholog of human TONSL (tonsoku like, DNA repair protein).