gene: crml-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activating protein binding activity. Involved in several processes, including axon guidance; negative regulation of Rac protein signal transduction; and regulation of axon extension involved in axon guidance. Located in plasma membrane. Expressed in several structures, including distal tip cell; epithelial cell; excretory canal; neurons; and vulva. Human ortholog(s) of this gene implicated in immunodeficiency 58. Is an ortholog of human CARMIL1 (capping protein regulator and myosin 1 linker 1); CARMIL2 (capping protein regulator and myosin 1 linker 2); and CARMIL3 (capping protein regulator and myosin 1 linker 3).