gene: sli-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of vulval development. Predicted to be located in membrane raft and plasma membrane. Expressed in several structures, including anal depressor muscle; body wall musculature; distal tip cell; head; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung squamous cell carcinoma. Is an ortholog of human CBL (Cbl proto-oncogene); CBLB (Cbl proto-oncogene B); and CBLC (Cbl proto-oncogene C).