Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in cholesterol homeostasis. Located in nucleus. Expressed in intestinal cell. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); autosomal recessive limb-girdle muscular dystrophy type 2B; carcinoma (multiple); and lung disease (multiple). Is an ortholog of human VDR (vitamin D receptor).
Is affected by several genes including rrf-3; unc-30; and nhr-8 based on RNA-seq and microarray studies. Is affected by cholesterol based on RNA-seq studies.