gene: par-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calmodulin binding activity and protein serine/threonine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell division; and determination of adult lifespan. Located in cell cortex. Expressed widely. Used to study Peutz-Jeghers syndrome. Human ortholog(s) of this gene implicated in several diseases, including Peutz-Jeghers syndrome; familial melanoma; and female reproductive organ cancer (multiple). Is an ortholog of human STK11 (serine/threonine kinase 11).
gene: strd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including asymmetric neuroblast division; maintenance of dauer; and positive regulation of peptidyl-threonine phosphorylation. Located in several cellular components, including cell body; cell cortex; and neuron projection. Expressed in excretory canal; nervous system; and pharynx. Is an ortholog of human STRADA (STE20 related adaptor alpha) and STRADB (STE20 related adaptor beta).