gene: frk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables beta-catenin binding activity and protein kinase activity. Involved in several processes, including embryonic body morphogenesis; negative regulation of canonical Wnt signaling pathway; and regulation of epidermal cell differentiation. Located in several cellular components, including cell-cell junction; nucleus; and plasma membrane. Expressed in several structures, including germ line; hermaphrodite gonad; hypodermis; intestine; and sperm. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Is an ortholog of human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase).