gene: alp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Involved in determination of adult lifespan and pharyngeal pumping. Located in several cellular components, including actin filament bundle; basal part of cell; and striated muscle dense body. Expressed in body wall musculature; hypodermis; marginal cell; and pharyngeal muscle cell. Used to study cardiomyopathy and myopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1C; distal myopathy; myofibrillar myopathy 4; and myotonic dystrophy type 1. Is an ortholog of human PDLIM5 (PDZ and LIM domain 5).
sequence feature: WBsf716784
Caenorhabditis elegans This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=T11B7.4. Surounding gene organisation=tandem