Enables 5'-3' RNA exonuclease activity. Involved in several processes, including miRNA catabolic process; negative regulation of miRNA-mediated gene silencing; and regulation of vulval development. Located in nucleus. Expressed in M5 neuron; PVT; intestine; and pharyngeal epithelial cell. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; leiomyosarcoma; and lung cancer. Is an ortholog of human XRN2 (5'-3' exoribonuclease 2).
Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex and preribosome, large subunit precursor. Is an ortholog of human BOP1 (BOP1 ribosomal biogenesis factor).
This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=Y48B6A.7. Surounding gene organisation=tandem
This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=Y48B6A.5. Surounding gene organisation=divergent