gene: grh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific double-stranded DNA binding activity. Involved in defense response to bacterium; determination of adult lifespan; and ecdysis, collagen and cuticulin-based cuticle. Located in nucleus. Part of chromatin. Expressed in head neurons; hypodermal cell; pharyngeal cell; seam cell; and vulval precursor cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Is an ortholog of human GRHL1 (grainyhead like transcription factor 1); GRHL2 (grainyhead like transcription factor 2); and GRHL3 (grainyhead like transcription factor 3).
sequence feature: WBsf716646
Caenorhabditis elegans This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=Y48G8AR.1. Surounding gene organisation=divergent
sequence feature: WBsf717450
Caenorhabditis elegans This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=Y48G8AR.1. Surounding gene organisation=divergent