Enriched in PVP; arcade cell; head mesodermal cell; intestine; and mechanosensory neurons based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
daf-16;
skn-1; and
glp-1 based on microarray; RNA-seq; and proteomic studies. Is affected by fifteen chemicals including glutathione; nicotinic acid; and rotenone based on proteomic; RNA-seq; and microarray studies. Human HPGDS enables metal ion binding activity; prostaglandin-D synthase activity; and protein homodimerization activity. Is predicted to encode a protein with the following domains: Glutathione S-transferase, N-terminal; Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain; Glutathione S-transferase, C-terminal domain superfamily; Glutathione S-transferase, C-terminal; and Thioredoxin-like superfamily. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).