Enriched in muscle cell; neurons; and retrovesicular ganglion based on microarray studies. Is affected by several genes including
daf-16;
daf-2; and
skn-1 based on microarray; RNA-seq; and proteomic studies. Is affected by eighteen chemicals including Heme; Zidovudine; and Sodium Chloride based on microarray and RNA-seq studies. Human HPGDS enables metal ion binding activity; prostaglandin-D synthase activity; and protein homodimerization activity. Is predicted to encode a protein with the following domains: Glutathione S-transferase, N-terminal; Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain; Glutathione S-transferase, C-terminal domain superfamily; Glutathione S-transferase, C-terminal; and Thioredoxin-like superfamily. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).