gene: lis-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable dynein complex binding activity and microtubule plus-end binding activity. Involved in several processes, including chiasma assembly; microtubule-based process; and organelle localization. Located in cell cortex; perinuclear region of cytoplasm; and supramolecular complex. Part of cytoplasmic dynein complex. Expressed in several structures, including hermaphrodite gonad; hypodermis; neurons; preanal ganglion; and somatic nervous system. Used to study lissencephaly. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lissencephaly 1; and schizophrenia. Is an ortholog of human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1).