- gene: tyra-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and octopamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to be located in dendrite. Expressed in SDQ; gonad; head neurons; and vulva. Used to study Parkinson's disease.
- gene: tkr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable tachykinin receptor activity. Predicted to be involved in tachykinin receptor signaling pathway. Predicted to be located in plasma membrane. Expressed in ADEsoL; ADEsoR; PDEsoL; and PDEsoR. Human ortholog(s) of this gene implicated in exercise-induced bronchoconstriction and hypogonadotropic hypogonadism 11 with or without anosmia. Is an ortholog of human TACR1 (tachykinin receptor 1) and TACR3 (tachykinin receptor 3).
- gene: daf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of dauer larval development; and regulation of insulin receptor signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Expressed in several structures, including cuticle; excretory system; interfacial epithelial cell; neurons; and vulval cell. Is an ortholog of human PTCHD3 (patched domain containing 3 (gene/pseudogene)).
- gene: lit-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables beta-catenin binding activity and protein serine/threonine kinase activity. Involved in several processes, including cell fate commitment; polarity specification of proximal/distal axis; and positive regulation of nematode male tail tip morphogenesis. Located in cell cortex and nucleus. Part of serine/threonine protein kinase complex. Expressed in several structures, including hermaphrodite gonad; pharynx; tail hypodermis; and vulva. Is an ortholog of human NLK (nemo like kinase).
- gene: wrt-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable peptidase activity. Predicted to be involved in cell-cell signaling; protein autoprocessing; and system development. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in anterior ganglion (ant); hypodermis; and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human SHH (sonic hedgehog signaling molecule).
- gene: qua-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in molting cycle and nematode larval development. Acts upstream of or within nematode male tail mating organ morphogenesis. Located in collagen and cuticulin-based cuticle extracellular matrix. Expressed in several structures, including P1; P12; P2; excretory system; and hypodermal cell.