Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Expressed in excretory cell; hermaphrodite distal tip cell; intestine; neurons; and ventral nerve cord.
Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Predicted to be involved in several processes, including SMAD protein signal transduction; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Expressed in head neurons; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including aortic valve disease 2; idiopathic pulmonary fibrosis; and liver disease (multiple). Is an ortholog of human SMAD6 (SMAD family member 6) and SMAD7 (SMAD family member 7).
Predicted to enable mRNA binding activity. Predicted to be involved in miRNA processing. Predicted to be located in nucleus. Is an ortholog of human SNIP1 (Smad nuclear interacting protein 1).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; egg-laying behavior; and negative regulation of dauer larval development. Predicted to be part of heteromeric SMAD protein complex. Expressed in several structures, including anal sphincter muscle; excretory duct cell; intestine; nerve ring; and phasmid sheath cell.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of growth. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Expressed in head neurons and pseudocoelom. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and female reproductive organ cancer (multiple). Is an ortholog of human SMAD4 (SMAD family member 4).