- WBPaper00031132:LiCl_upregulated
Authors used two-sample t-tests for each gene and then used a FWER cut-off of 5% on the marginal p values using the Holms step-down method.
Gene transcript changes (up-regulated) in response to 10mM LiCl.
- WBPaper00031132:LiCl_downregulated
Authors used two-sample t-tests for each gene and then used a FWER cut-off of 5% on the marginal p values using the Holms step-down method.
Gene transcript changes (down-regulated) in response to 10mM LiCl.
- WBPaper00028344:adult_expr_change
Authors searched for targets with seed matches of perfect Watson-Crick base-pair complementarity to positions two-eight of the miRNAs (counting from the 5' end). In order to consider these seed matches as potential target sites, authors required a minimal cut-off for binding specificity of the remainder of the miRNA to the target. Recent evidence suggests that this is not required for function in humans, but 3' binding does occur in studies of C. elegans. Authors used the scoring algorithm from Robins et al. (2005). The binding cut-off is determined by creating a second-order Markov model of the background for the 3' UTRs. The cut off was p-value < = 0.05.
micro RNAs that exhibit changes in expression during adulthood (p-value < = 0.05).
- WBPaper00050767:Octopamine_induced
Fold-Change cut-off : 2.0
Transcripts that showed significantly increased expression after young adult animals were treated with 20ml per ml Octopamine for 2 days.
- WBPaper00037704:ABZ_up_regulated
The rank products algorithm was used to assess differential expression of genes between test and control groups, and to assign significance to these changes. Assignment of significance was carried out using an FDR (false discovery rate) cut-off of 5 - 10%.
Significantly up-regulated genes (FDR< 10%) following exposure of C. elegans to albendazole.
- WBPaper00037704:ABZ_down_regulated
The rank products algorithm was used to assess differential expression of genes between test and control groups, and to assign significance to these changes. Assignment of significance was carried out using an FDR (false discovery rate) cut-off of 5 - 10%.
Significantly down-regulated genes (FDR< 10%) following exposure of C. elegans to albendazole.
- WBPaper00042165:let-7_upregulated
Paired t-test. Expression level change of more than 2 fold is the cut-off.
Genes up-regulated more than 2-fold in let-7(n2853) compared to wild-type.