- WBPaper00040755:LRRK2(R1441C)-Tau_vs_Tau_downregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed increased expression in a strain expressing human LRRK2(R1441C) mutant and V377M Tau, comparing to in animals expressing Tau(V337M) only.
- WBPaper00053154:human-amyloid-beta_tau_regulated
To identify differential gene expression, analysis was performed using CuffLinks 2.2.1 with false discovery rate corrected P values (q values) of < 0.05 and log2 (fold change) > 1 or < 1.
Transcripts that showed differential expression between N2 and animals expressing human amyloid beta peptide (strain CL2355) and pro-aggregating tau (strain BR5270) or anti-aggregating tau protein (BR5271), at L4 larva stage.
- WBPaper00040755:LRRK2(wt)-Tau_vs_Tau_upregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed increased expression in a strain expressing wildtype human LRRK2 and V377M Tau, comparing to in animals expressing Tau(V337M) only.
- WBPaper00040755:LRRK2(R1441C)-Tau_vs_Tau_upregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed increased expression in a strain expressing human LRRK2(R1441C) mutant and V377M Tau, comparing to in animals expressing Tau(V337M) only.
- WBPaper00040755:LRRK2(G2019S)-Tau_vs_Tau_downregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed increased expression in a strain expressing human LRRK2(G2019S) mutant and V377M Tau, comparing to in animals expressing Tau(V337M) only.
- WBPaper00040755:LRRK2(wt)-Tau_vs_Tau_downregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed decreased expression in a strain expressing wildtype human LRRK2 and V377M Tau, comparing to in animals expressing Tau(V337M) only.
- WBPaper00040755:LRRK2(G2019S)-Tau_vs_Tau_upregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed increased expression in a strain expressing human LRRK2(G2019S) mutant and V377M Tau, comparing to in animals expressing Tau(V337M) only.
- WBPaper00040755:LRRK2(G2019S)-Tau_vs_N2_downregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed increased expression in a strain expressing human LRRK2(G2019S) mutant and V377M Tau, comparing to in N2 animals.
- WBPaper00040755:LRRK2(G2019S)-Tau_vs_N2_upregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed increased expression in a strain expressing human LRRK2(G2019S) mutant and V377M Tau, comparing to in N2 animals.
- WBPaper00040755:LRRK2(wt)-Tau_vs_N2_downregulated
Statistical analysis of protein levels matched with spots on 2D-gels from mutated LRRK2::Tau transgenic strains compared Non-T and Tau transgenic strains were carried out using Student's t-tests. A value of p < 0.05 was considered statistically significant. Only proteins that were considered significantly different by Student's t-test were subjected to in-gel trypsin digestion and subsequent proteomic analysis.
Proteins that showed decreased expression in a strain expressing wildtype human LRRK2 and V377M Tau, comparing to in N2 animals.