Enables cAMP response element binding protein binding activity. Involved in determination of adult lifespan. Located in cytosol and nucleus. Expressed in RICL; RICR; head neurons; intestine; and tail neurons. Is an ortholog of human CRTC1 (CREB regulated transcription coactivator 1).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).