Enables POZ domain binding activity. Involved in cell development and protein metabolic process. Part of Cul3-RING ubiquitin ligase complex. Expressed in head; linker cell; and tail. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Is an ortholog of human CUL3 (cullin 3).
Predicted to enable ubiquitin protein ligase binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Expressed in embryonic cell; germ line; gonad; intestine; and oocyte. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Is an ortholog of human CUL4B (cullin 4B).
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Expressed in several structures, including head; intestine; nervous system; tail; and vulval muscle. Is an ortholog of human CUL5 (cullin 5).
Predicted to enable DNA binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm; nucleus; and site of double-strand break. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and rectum. Used to study xeroderma pigmentosum. Is an ortholog of human DDB1 (damage specific DNA binding protein 1).
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cell cycle; and regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Expressed in intestine; muscle cell; and neurons. Is an ortholog of human CUL1 (cullin 1).
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of metaphase/anaphase transition of meiotic cell cycle; and reproductive process. Located in cytoplasm and nucleus. Part of Cul2-RING ubiquitin ligase complex. Expressed in several structures, including P1; P12; P2; germ line; and nerve ring. Is an ortholog of human CUL2 (cullin 2).
Enables ubiquitin binding activity. Involved in microtubule cytoskeleton organization and protein metabolic process. Located in cytoplasm and nucleus. Is an ortholog of human DCUN1D1 (defective in cullin neddylation 1 domain containing 1) and DCUN1D2 (defective in cullin neddylation 1 domain containing 2).
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in defense response to virus. Predicted to be part of SCF ubiquitin ligase complex. Expressed in intestine and pharynx. Is an ortholog of human CUL1 (cullin 1).