- egl-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatidylinositol phospholipase C activity. Involved in several processes, including dopamine receptor signaling pathway; positive regulation of acetylcholine secretion, neurotransmission; and taxis. Located in plasma membrane. Expressed in intestine; nervous system; non-striated muscle; and vas deferens. Used to study nicotine dependence. Is an ortholog of human PLCB4 (phospholipase C beta 4).
- mau-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in body wall musculature; germ line; hypodermis; intestine; and pharynx. Is predicted to encode a protein with the following domains: Phosducin, N-terminal domain superfamily; Phosducin; Thioredoxin-like superfamily; and Phosducin, thioredoxin-like domain. Is an ortholog of human PDC (phosducin) and PDCL (phosducin like).
- egl-38 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including developmental process involved in reproduction; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of chromatin. Expressed in body wall musculature; egg-laying apparatus; head neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital nongoitrous hypothyroidism 2; focal segmental glomerulosclerosis 7; and renal Wilms' tumor. Is an ortholog of human PAX2 (paired box 2); PAX5 (paired box 5); and PAX8 (paired box 8).
- egl-47 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and egg-laying behavior. Predicted to be located in axon; membrane; and somatodendritic compartment. Expressed in HSNL; HSNR; PVQL; PVQR; and vulva.
- egl-46 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including detection of chemical stimulus; generation of neurons; and positive regulation of exit from mitosis. Located in nucleus. Expressed in several structures, including QL.aa; QL.pp; QR.aa; QR.pp; and neurons. Is an ortholog of human INSM2 (INSM transcriptional repressor 2).