Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and regulation of DNA-templated transcription. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Located in nucleus. Part of transcription regulator complex. Expressed widely. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Is an ortholog of human HCFC1 (host cell factor C1) and HCFC2 (host cell factor C2).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).