Enables protein phosphatase 2B binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including male mating behavior; positive regulation of nematode male tail tip morphogenesis; and thermosensory behavior. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including non-striated muscle; pharyngeal cell; somatic nervous system; tail; and vulva. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human RCAN1 (regulator of calcineurin 1); RCAN2 (regulator of calcineurin 2); and RCAN3 (RCAN family member 3).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).