Predicted to enable serine C-palmitoyltransferase activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be located in endoplasmic reticulum. Expressed in head. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A. Is an ortholog of human SPTLC1 (serine palmitoyltransferase long chain base subunit 1).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).