Enables mitogen-activated protein kinase kinase kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including defense response to other organism; positive regulation of antimicrobial peptide production; and positive regulation of axon regeneration. Expressed in tail. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 3; fatty liver disease; and portal hypertension. Is an ortholog of human PRKCD (protein kinase C delta) and PRKCQ (protein kinase C theta).
Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in antifungal innate immune response and positive regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including excretory cell; intestine; nerve ring; neurons; and pharynx. Is an ortholog of human GNA12 (G protein subunit alpha 12) and GNA13 (G protein subunit alpha 13).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).