Involved in response to hypoxia. Part of Cul2-RING ubiquitin ligase complex. Expressed in several structures, including ADFL and ADFR. Used to study clear cell renal cell carcinoma and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial erythrocytosis 2; and von Hippel-Lindau disease. Is an ortholog of human VHL (von Hippel-Lindau tumor suppressor).
Is affected by several genes including daf-2; clk-1; and vhl-1 based on microarray and tiling array studies. Is affected by Quercetin and single-walled carbon nanotube based on microarray studies.
Predicted to enable tubulin binding activity. Predicted to be involved in microtubule-based process and tubulin complex assembly. Located in cytoplasm. Expressed in body wall musculature; head muscle; oocyte; pharyngeal muscle cell; and vulval muscle. Is an ortholog of human VBP1 (VHL binding protein 1).
Predicted to enable actin binding activity. Located in I band. Expressed in anal depressor muscle; body wall musculature; male gonad; and pharyngeal muscle cell.
Predicted to enable cullin family protein binding activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intracellular signal transduction; positive regulation of metaphase/anaphase transition of meiotic cell cycle; and sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation. Part of Cul2-RING ubiquitin ligase complex. Expressed in germ line; gonad; linker cell; and oocyte. Is an ortholog of human RBX1 (ring-box 1).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).
Enables protein domain specific binding activity and protein-macromolecule adaptor activity. Involved in anterior/posterior axis specification, embryo; positive regulation of metaphase/anaphase transition of meiotic cell cycle; and sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation. Part of Cul2-RING ubiquitin ligase complex. Expressed in hypodermis; pharynx; and vulval muscle. Is an ortholog of human ELOC (elongin C).