Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules.
Enables neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Predicted to be located in plasma membrane. Is an ortholog of human NMUR1 (neuromedin U receptor 1) and NMUR2 (neuromedin U receptor 2).
Pyrokinin 1 receptor (PK1-R) encodes a seven transmembrane G-protein coupled receptor. It is thought to be a receptor for the neuropeptides encoded by Capa and Lst. It regulates the production and release of insulin.
Capability receptor (CapaR) encodes a G-protein-coupled receptor for the neuropeptide encoded by Capa, which stimulates fluid secretion in Malpighian tubules, thus acting as a diuretic hormone.