Predicted to enable actin filament binding activity and structural molecule activity. Involved in epidermis morphogenesis. Located in apical plasma membrane; basal plasma membrane; and hemidesmosome. Expressed in several structures, including gonad; intestinal lumen; nerve ring; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex; hereditary sensory and autonomic neuropathy type 6; and lissencephaly 9 with complex brainstem malformation. Is an ortholog of human DST (dystonin).
Predicted to enable metal ion binding activity. Involved in inductive cell migration; regulation of growth; and reproduction. Located in mitochondrion. Is an ortholog of human TIMM10B (translocase of inner mitochondrial membrane 10B).
Orthologous to human LRRC10B (leucine rich repeat containing 10B); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-Tetrachlorodibenzofuran; 2-methoxyethanol.
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Expressed in pharyngeal muscle cell and rectal epithelium. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).
ASSOCIATED WITH distal hereditary motor neuronopathy type 7A; ectodermal dysplasia 10A; ectodermal dysplasia 10B; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine
Enables GTPase activating protein binding activity. Involved in molting cycle. Is an ortholog of human RABEP1 (rabaptin, RAB GTPase binding effector protein 1).
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and ovulation. Expressed in spermatheca. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).