Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in cataract 48. Is an ortholog of human DNMBP (dynamin binding protein).
Enables sequence-specific DNA binding activity. Involved in dauer larval development and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail ganglion. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B).
Predicted to be involved in endoplasmic reticulum tubular network organization and membrane organization. Predicted to be located in endoplasmic reticulum. Is an ortholog of human TMEM33 (transmembrane protein 33).
Predicted to enable nicotinate phosphoribosyltransferase activity. Predicted to be involved in NAD salvage and response to oxidative stress. Predicted to be located in cytosol. Is an ortholog of human NAPRT (nicotinate phosphoribosyltransferase).
Predicted to enable sterol binding activity and sterol transporter activity. Predicted to be involved in sterol transport. Predicted to be located in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Human ortholog(s) of this gene implicated in cholangiocarcinoma and colorectal cancer. Is an ortholog of human OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2).
Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Is an ortholog of human IL17A (interleukin 17A); IL17C (interleukin 17C); and IL17F (interleukin 17F).
Predicted to enable palmitoyl-(protein) hydrolase activity. Involved in regulation of postsynapse organization. Is active in glutamatergic synapse. Orthologous to human ABHD17C (abhydrolase domain containing 17C, depalmitoylase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Predicted to enable cytokine activity. Predicted to be involved in inflammatory response and signal transduction. Predicted to act upstream of or within neutrophil differentiation and positive regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. Orthologous to human IL17C (interleukin 17C); INTERACTS WITH trichloroethene; 17beta-estradiol (ortholog); 4,4'-diaminodiphenylmethane (ortholog).
This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]