The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Predicted to enable transcription cis-regulatory region binding activity. Involved in determination of adult lifespan; programmed cell death; and transdifferentiation. Located in nucleus. Part of MLL3/4 complex. Expressed in germ line. Is an ortholog of human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit).
Predicted to be part of Set1C/COMPASS complex. Is an ortholog of C. elegans ash-2. In C. elegans, ash-2 is involved in determination of adult lifespan; programmed cell death; and transdifferentiation.
Predicted to be part of Set1C/COMPASS complex. Is an ortholog of C. elegans ash-2. In C. elegans, ash-2 is involved in determination of adult lifespan; programmed cell death; and transdifferentiation.
Predicted to be part of Set1C/COMPASS complex. Is an ortholog of C. elegans ash-2. In C. elegans, ash-2 is involved in determination of adult lifespan; programmed cell death; and transdifferentiation.
Predicted to be part of Set1C/COMPASS complex. Is an ortholog of C. elegans ash-2. In C. elegans, ash-2 is involved in determination of adult lifespan; programmed cell death; and transdifferentiation.
Predicted to be part of Set1C/COMPASS complex. Is an ortholog of C. elegans ash-2. In C. elegans, ash-2 is involved in determination of adult lifespan; programmed cell death; and transdifferentiation.
Predicted to be part of Set1C/COMPASS complex. Is an ortholog of C. elegans ash-2. In C. elegans, ash-2 is involved in determination of adult lifespan; programmed cell death; and transdifferentiation.