{"type":"gene","species":null,"uri":"search/gene/B0252.2/all","results":[{"page_type":"gene","label":"asm-1","legacy_description":"asm-1 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase; the ASM-1 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-1 shows phosphodiesterase activity when expressed in COS-7 cells; while mammalian ASM is detected as both intracellular and secreted forms, asm-1 was detected exclusively in the secreted form; northern blot analysis indicates that asm-1 is expressed at higher levels in the embryo compared with other stages.","description":"Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Located in extracellular region and lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease type A and Niemann-Pick disease type B. Is an ortholog of human SMPD1 (sphingomyelin phosphodiesterase 1).","taxonomy":{"id":"c_elegans","genus":"Caenorhabditis","species":"elegans"},"dead":false,"name":{"other_names":["B0252.2","CELE_B0252.2","B0252.2","B0252.2.1","CE30230"],"class":"gene","label":"asm-1","highlight":{"other_names":["B0252.2","B0252.2"]},"id":"WBGene00000211","taxonomy":"c_elegans"},"wbid":"WBGene00000211","species":{"key":"c_elegans","name":"Caenorhabditis elegans"},"allele":[{"class":"variation","label":"gk145886","id":"WBVar00369129"},{"id":"WBVar00741005","label":"gk777925","class":"variation"},{"id":"WBVar00740999","class":"variation","label":"gk697998"},{"class":"variation","label":"tm5267","id":"WBVar00597563"},{"class":"variation","label":"gk145885","id":"WBVar00369128"},{"label":"gk145887","class":"variation","id":"WBVar00369130"},{"id":"WBVar00741002","class":"variation","label":"gk855790"},{"label":"gk785217","class":"variation","id":"WBVar00740998"},{"label":"tm8025","class":"variation","id":"WBVar02145196"},{"label":"gk565644","class":"variation","id":"WBVar00741006"},{"id":"WBVar00740996","label":"gk601116","class":"variation"},{"id":"WBVar01498435","label":"gk963053","class":"variation"},{"class":"variation","label":"tm5023","id":"WBVar00317302"},{"id":"WBVar00740997","class":"variation","label":"gk836303"},{"id":"WBVar00741000","class":"variation","label":"gk787796"},{"id":"WBVar00741007","class":"variation","label":"gk578124"},{"id":"WBVar00088238","class":"variation","label":"kk1"},{"label":"gk958236","class":"variation","id":"WBVar01493973"},{"id":"WBVar01499702","label":"gk963801","class":"variation"},{"id":"WBVar00741004","label":"gk655674","class":"variation"},{"class":"variation","label":"gk527153","id":"WBVar00741003"},{"label":"gk832037","class":"variation","id":"WBVar00741001"},{"id":"WBVar00740995","label":"gk569833","class":"variation"}],"other_names":["B0252.2","CELE_B0252.2","B0252.2","B0252.2.1","CE30230"],"merged_into":null}],"query":"B0252.2","page":"all","count":1}