tsp-17 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables D2 dopamine receptor binding activity. Involved in cellular response to paraquat; negative regulation of response to oxidative stress; and regulation of dopamine uptake involved in synaptic transmission. Located in neuron projection; perinuclear region of cytoplasm; and plasma membrane. Expressed in several structures, including NSM; body wall musculature; dopaminergic neurons; hermaphrodite gonad; and vulva. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Is an ortholog of human TSPAN3 (tetraspanin 3) and TSPAN7 (tetraspanin 7).