--- count: 1 page: all query: C06H2.4 results: - allele: - class: variation id: WBVar01495388 label: gk959651 - class: variation id: WBVar01046916 label: gk687706 - class: variation id: WBVar01046914 label: gk359894 - class: variation id: WBVar01500208 label: gk964451 - class: variation id: WBVar01046920 label: gk809279 - class: variation id: WBVar01046919 label: gk502952 - class: variation id: WBVar01046913 label: gk642895 - class: variation id: WBVar01046921 label: gk695551 - class: variation id: WBVar00092674 label: ok1460 - class: variation id: WBVar01499316 label: gk963301 - class: variation id: WBVar01046915 label: gk452455 - class: variation id: WBVar00470115 label: gk246872 - class: variation id: WBVar01046918 label: gk324180 - class: variation id: WBVar01499299 label: gk963271 - class: variation id: WBVar00470114 label: gk246871 - class: variation id: WBVar01046911 label: gk678697 - class: variation id: WBVar01046910 label: gk511303 - class: variation id: WBVar01500209 label: gk964452 - class: variation id: WBVar01046917 label: gk575804 - class: variation id: WBVar01046912 label: gk636463 dead: !!perl/scalar:JSON::PP::Boolean 0 description: Predicted to enable folic acid binding activity and vitamin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Expressed in head; head muscle; and tail. Human ortholog(s) of this gene implicated in several diseases, including biotin-responsive basal ganglia disease; cleft lip; and dextro-looped transposition of the great arteries. Is an ortholog of human SLC19A3 (solute carrier family 19 member 3). label: folt-1 legacy_description: folt-1 encodes a folate transporter required for folate uptake; FOLT-1 is orthologous to the human folate transporter, SLC19A3 (Solute Carrier Family 19 (thiamine transporter), Member 3); folt-1 is required for proper germline function, oogenesis and sperm number in males, and for normal life-span; folt-1 mutants and folt-1(RNAi) animals show significantly lowered folate uptake; heterologously expressed FOLT-1 transports folate in vitro; FOLT-1 activity is acid-dependent, is sodium-independent, and is inhibited by folate derivatives, sulfasalazine, or anion transport inhibitors such as 4,4''-diisothio-cyanatostilbene-2,2''-disulphonic acid (DIDS); folt-1 is expressed in several tissues, including (most strongly) pharynx and posterior intestine, as well as head, body wall, vulva muscles, and gonad sheath cells. merged_into: ~ name: class: gene highlight: other_names: - C06H2.4 - C06H2.4 id: WBGene00007388 label: folt-1 other_names: - C06H2.4 - tag-330 - CELE_C06H2.4 - CE47283 - C06H2.4 - C06H2.4.1 taxonomy: c_elegans other_names: - C06H2.4 - tag-330 - CELE_C06H2.4 - CE47283 - C06H2.4 - C06H2.4.1 page_type: gene species: key: c_elegans name: Caenorhabditis elegans taxonomy: genus: Caenorhabditis id: c_elegans species: elegans wbid: WBGene00007388 species: ~ type: gene uri: search/gene/C06H2.4/all