---
count: 1
page: all
query: C06H2.4
results:
-
allele:
-
class: variation
id: WBVar01495388
label: gk959651
-
class: variation
id: WBVar01046916
label: gk687706
-
class: variation
id: WBVar01046914
label: gk359894
-
class: variation
id: WBVar01500208
label: gk964451
-
class: variation
id: WBVar01046920
label: gk809279
-
class: variation
id: WBVar01046919
label: gk502952
-
class: variation
id: WBVar01046913
label: gk642895
-
class: variation
id: WBVar01046921
label: gk695551
-
class: variation
id: WBVar00092674
label: ok1460
-
class: variation
id: WBVar01499316
label: gk963301
-
class: variation
id: WBVar01046915
label: gk452455
-
class: variation
id: WBVar00470115
label: gk246872
-
class: variation
id: WBVar01046918
label: gk324180
-
class: variation
id: WBVar01499299
label: gk963271
-
class: variation
id: WBVar00470114
label: gk246871
-
class: variation
id: WBVar01046911
label: gk678697
-
class: variation
id: WBVar01046910
label: gk511303
-
class: variation
id: WBVar01500209
label: gk964452
-
class: variation
id: WBVar01046917
label: gk575804
-
class: variation
id: WBVar01046912
label: gk636463
dead: !!perl/scalar:JSON::PP::Boolean 0
description: Predicted to enable folic acid binding activity and vitamin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Expressed in head; head muscle; and tail. Human ortholog(s) of this gene implicated in several diseases, including biotin-responsive basal ganglia disease; cleft lip; and dextro-looped transposition of the great arteries. Is an ortholog of human SLC19A3 (solute carrier family 19 member 3).
label: folt-1
legacy_description: folt-1 encodes a folate transporter required for folate uptake; FOLT-1 is orthologous to the human folate transporter, SLC19A3 (Solute Carrier Family 19 (thiamine transporter), Member 3); folt-1 is required for proper germline function, oogenesis and sperm number in males, and for normal life-span; folt-1 mutants and folt-1(RNAi) animals show significantly lowered folate uptake; heterologously expressed FOLT-1 transports folate in vitro; FOLT-1 activity is acid-dependent, is sodium-independent, and is inhibited by folate derivatives, sulfasalazine, or anion transport inhibitors such as 4,4''-diisothio-cyanatostilbene-2,2''-disulphonic acid (DIDS); folt-1 is expressed in several tissues, including (most strongly) pharynx and posterior intestine, as well as head, body wall, vulva muscles, and gonad sheath cells.
merged_into: ~
name:
class: gene
highlight:
other_names:
- C06H2.4
- C06H2.4
id: WBGene00007388
label: folt-1
other_names:
- C06H2.4
- tag-330
- CELE_C06H2.4
- CE47283
- C06H2.4
- C06H2.4.1
taxonomy: c_elegans
other_names:
- C06H2.4
- tag-330
- CELE_C06H2.4
- CE47283
- C06H2.4
- C06H2.4.1
page_type: gene
species:
key: c_elegans
name: Caenorhabditis elegans
taxonomy:
genus: Caenorhabditis
id: c_elegans
species: elegans
wbid: WBGene00007388
species: ~
type: gene
uri: search/gene/C06H2.4/all