--- count: 1 page: all query: C25F6.3 results: - allele: - class: variation id: WBVar01147606 label: gk829123 - class: variation id: WBVar00503840 label: gk280597 - class: variation id: WBVar01147600 label: gk412813 - class: variation id: WBVar01147605 label: gk677110 - class: variation id: WBVar00503838 label: gk280595 - class: variation id: WBVar02139300 label: h12508 - class: variation id: WBVar01147603 label: gk379785 - class: variation id: WBVar01147591 label: gk785725 - class: variation id: WBVar01147616 label: gk616925 - class: variation id: WBVar01147613 label: gk813225 - class: variation id: WBVar01147614 label: gk861849 - class: variation id: WBVar00503837 label: gk280594 - class: variation id: WBVar01147619 label: gk366968 - class: variation id: WBVar01147625 label: gk738223 - class: variation id: WBVar01147621 label: gk829874 - class: variation id: WBVar01147611 label: gk555938 - class: variation id: WBVar00503836 label: gk280593 - class: variation id: WBVar01147590 label: gk666255 - class: variation id: WBVar01147608 label: gk551363 - class: variation id: WBVar01147617 label: gk674892 - class: variation id: WBVar00503842 label: gk280599 - class: variation id: WBVar02139299 label: h5860 - class: variation id: WBVar01147626 label: gk742435 - class: variation id: WBVar01147602 label: gk373396 - class: variation id: WBVar01147627 label: gk385952 - class: variation id: WBVar01147622 label: gk410714 - class: variation id: WBVar00503835 label: gk280592 - class: variation id: WBVar01147592 label: gk534439 - class: variation id: WBVar01147597 label: gk631959 - class: variation id: WBVar00503834 label: gk280591 - class: variation id: WBVar01147594 label: gk635397 - class: variation id: WBVar01147628 label: gk837827 - class: variation id: WBVar01147609 label: gk551364 - class: variation id: WBVar01147607 label: gk758279 - class: variation id: WBVar01147599 label: gk621159 - class: variation id: WBVar00503841 label: gk280598 - class: variation id: WBVar01500067 label: gk964260 - class: variation id: WBVar01147595 label: gk673107 - class: variation id: WBVar01147612 label: gk519179 - class: variation id: WBVar01147604 label: gk788225 - class: variation id: WBVar01147610 label: gk589079 - class: variation id: WBVar01147624 label: gk570090 - class: variation id: WBVar01147618 label: gk537849 - class: variation id: WBVar01147593 label: gk829873 - class: variation id: WBVar01492588 label: gk956851 - class: variation id: WBVar00503839 label: gk280596 - class: variation id: WBVar01147620 label: gk464351 - class: variation id: WBVar01147623 label: gk895323 - class: variation id: WBVar01147596 label: gk773392 - class: variation id: WBVar01147601 label: gk849678 - class: variation id: WBVar01147615 label: gk484733 - class: variation id: WBVar01147589 label: gk760329 - class: variation id: WBVar01147598 label: gk488370 dead: !!perl/scalar:JSON::PP::Boolean 0 description: Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and gallbladder cancer. Is an ortholog of human DPYD (dihydropyrimidine dehydrogenase). label: dpyd-1 legacy_description: dpyd-1 encodes the C. elegans ortholog of human DihydroPYrimidine Dehydrogenase (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270); DPYD-1 is the first and rate-limiting enzyme for uracil and thymine metabolism to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively, and in humans, functions in metabolism of the anti-cancer pyrimidine antagonist 5-fluorouracil (5-FU); in C. elegans, loss of dpyd-1 activity via RNAi results in sensitivity (decreased survival) to 5-FU while conversely, DPYD-1 overexpression affords increased germ cell survivability to 5-FU. merged_into: ~ name: class: gene highlight: other_names: - C25F6.3 - C25F6.3 id: WBGene00016103 label: dpyd-1 other_names: - C25F6.3 - CELE_C25F6.3 - CE38489 - C25F6.3 - C25F6.3.1 taxonomy: c_elegans other_names: - C25F6.3 - CELE_C25F6.3 - CE38489 - C25F6.3 - C25F6.3.1 page_type: gene species: key: c_elegans name: Caenorhabditis elegans taxonomy: genus: Caenorhabditis id: c_elegans species: elegans wbid: WBGene00016103 species: ~ type: gene uri: search/gene/C25F6.3/all