apl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable heparin binding activity and transition metal ion binding activity. Involved in body morphogenesis; ecdysis, collagen and cuticulin-based cuticle; and nematode larval development. Located in cytoplasmic vesicle; neuron projection; and neuronal cell body. Expressed in several structures, including epithelial cell; excretory cell; hermaphrodite gonad; neurons; and somatic nervous system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including APP-related cerebral amyloid angiopathy; Alzheimer's disease 1; traumatic brain injury; and visual epilepsy. Is an ortholog of human APLP2 (amyloid beta precursor like protein 2).