tbp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity; RNA polymerase II general transcription initiation factor binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in positive regulation of DNA-templated transcription. Located in nucleus. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; sleep apnea; and type 1 diabetes mellitus. Is an ortholog of human TBP (TATA-box binding protein) and TBPL2 (TATA-box binding protein like 2).