gsr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables glutathione-disulfide reductase (NADP) activity. Involved in several processes, including cell redox homeostasis; ecdysis, collagen and cuticulin-based cuticle; and response to superoxide. Located in cytosol and mitochondrion. Expressed in several structures, including Epr; Epra; coelomocyte; excretory canal; and hermaphrodite gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cataract (multiple); hematologic cancer (multiple); and hemolytic anemia (multiple). Is an ortholog of human GSR (glutathione-disulfide reductase).