frh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in determination of adult lifespan; response to hydrogen peroxide; and response to superoxide. Located in mitochondrion. Expressed in amphid neurons; body wall musculature; pharyngeal muscle cell; and spermatheca. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia 1 and type 2 diabetes mellitus. Is an ortholog of human FXN (frataxin).